【研究】mRNAワクチン接種後、精液量と精子の運動性、大幅増加　無精子症になった人はいない [マスク着用のお願い★]

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https://jamanetwork.com/journals/jama/fullarticle/2781360?guestAccessKey=17114e03-640c-4688-b1c2-9ed8b936c3cd&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=061721

Sperm Parameters Before and After COVID-19 mRNA Vaccination

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Results
Between December 17, 2020, and January 12, 2021, 45 men volunteered (median age, 28 years [IQR, 25-31]); follow-up samples were obtained at a median of 75 days (IQR, 70-86) after the second dose. The study ended on April 24, 2021. Baseline samples were obtained after a median abstinence period of 2.8 days (IQR, 2-3) and follow-up samples after a median of 3 days (IQR, 3-4). Of the 45 men, 21 (46.7%) received BNT162b2 and 24 (53.3%) received mRNA-1273. Baseline sperm concentration and TMSC were 26 million/mL (IQR, 19.5-34) and 36 million (IQR, 18-51), respectively. After the second vaccine dose, the median sperm concentration significantly increased to 30 million/mL (IQR, 21.5-40.5; P = .02) and the median TMSC to 44 million (IQR, 27.5-98; P = .001). Semen volume and sperm motility also significantly increased (Table).

Eight of the 45 men were oligospermic before the vaccine (median concentration, 8.5 million/mL [IQR, 5.1-12]). Of these 8, 7 men had increased sperm concentration to normozoospermic range at follow-up (median concentration, 22 million/mL [IQR, 17-25.5]), and 1 man remained oligospermic. No man became azoospermic after the vaccine.

The waterfall plot shows the within-participant change in TMSC from baseline (range, −22 million to 93 million) for each man (Figure).
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Daniel C. Gonzalez, BS1; Daniel E. Nassau, MD1; Kajal Khodamoradi, PhD1; et al

JAMA. Published online June 17, 2021. doi:10.1001/jama.2021.9976

【研究】mRNAワクチン接種後、精液量と精子の運動性、大幅増加 無精子症になった人はいない [マスク着用のお願い★]

【研究】mRNAワクチン接種後、精液量と精子の運動性、大幅増加　無精子症になった人はいない [マスク着用のお願い★]